What protein is affected by prostate cancer?

Scientists have demonstrated how a protein called TRAP1 – an important regulator of energy production in healthy and cancerous cells – is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease.

What does the EZH2 gene do?

The EZH2 gene provides instructions for making a type of enzyme called a histone methyltransferase. Histone methyltransferases modify proteins called histones, which are structural proteins that attach (bind) to DNA and give chromosomes their shape.

What genes are involved in prostate cancer?

Inherited variants in particular genes, such as BRCA1, BRCA2, and HOXB13, account for some cases of hereditary prostate cancer. Men with variants in these genes have a high risk of developing prostate cancer and, in some cases, other cancers during their lifetimes.

What regulates EZH2?

EZH2 expression is indeed regulated by various oncogenic transcription factors, tumor suppressor miRNAs, and cancer-associated non-coding RNA. EZH2 activity is also controlled by post-translational modifications, which are deregulated in cancer.

Does protein affect the prostate?

Growing evidence demonstrated that dietary protein intake may be a risk factor for prostate cancer and elevate the level of prostate-specific antigen (PSA).

What is the cause of prostate cancer?

On a basic level, prostate cancer is caused by changes in the DNA of a normal prostate cell. DNA is the chemical in our cells that makes up our genes, which control how our cells function. We usually look like our parents because they are the source of our DNA. But DNA affects more than just how we look.

Is EZH2 a protein?

Further, EZH2 has been identified as an essential protein involved in development and differentiation of B-cells and T-cells.

What factors contribute to prostate cancer?

The following factors may raise a person’s risk of developing prostate cancer:

• Age.
• Race.
• North American or northern European location.
• Family history.
• Hereditary breast and ovarian cancer (HBOC) syndrome.
• Other genetic changes.
• Agent Orange exposure.
• Eating habits.

Is EZH2 a tumor suppressor?

EZH2 downregulates expression of tumor suppressor genes and upregulates oncogenes, promoting cancer cell survival, proliferation, epithelial to mesenchymal and invasion. In particular, EZH2 has been also reported to be associated with drug resistance to chemotherapy and targeted therapy.

What causes prostate cancer and how can it be prevented?

Poor eating habits and diets that heavily rely on fats and animal proteins can cause DNA damage and lead to cancer. Even men who are already at greater risk due to age, race or genetics can reduce their chances of developing prostate cancer by adopting healthy diets and lifestyles.

What is the pathophysiology of prostate cancer?

Prostate cancer develops when the rates of cell division exceed those of cell death, leading to uncontrolled tumor growth. Following the initial transformation event, further mutations of a multitude of genes, including the genes for p53 and retinoblastoma, can lead to tumor progression and metastasis.