What is the difference between vasculitis and HSP?

HSP is a specific small-vessel vasculitis associated with the presence of vascular IgA deposition. However, by definition, HSP is a clinically defined entity and some authorities may make this diagnosis even if IgA deposition is absent.

Is HSP leukocytoclastic vasculitis?

Henoch–Schönlein purpura (HSP) is a form of leukocytoclastic or small-vessel vasculitis, most often observed in children. It is sometimes called anaphylactoid purpura. HSP results from inflammation of the small blood vessels in the skin and various other tissues within the body.

What type of hypersensitivity is leukocytoclastic vasculitis?

Leukocytoclastic vasculitis (LCV) refers to small blood vessel inflammation. It’s also known as hypersensitivity vasculitis and hypersensitivity angiitis. The word “leukocytoclastic” comes from “leukocytoclasia,” a process where neutrophils (immune cells) break down and release debris.

What is hypersensitivity vasculitis?

Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and damage to blood vessels, mainly in the skin. The term is not used much currently because more specific names are considered more precise.

Is Leukocytoclastic vasculitis an autoimmune disease?

Leukocytoclastic vasculitis is a cutaneous, small-vessel vasculitis of the dermal capillaries and venules. This condition can be idiopathic or can be associated with infections, neoplasms, autoimmune disorders, and drugs.

Is ANA positive in HSP?

Last, but most important, there is some evidence of associated autoimmune disorder in patients with SLE or HSP. According to the study conducted by Swart and Wulffraat, ANA and anti-dsDNA were positive in 20% and 98% patients with mixed CTD, respectively [3].

What is leukocytoclastic?

The term leukocytoclastic refers to the debris of neutrophils (immune cells) within the blood vessel walls. The disease can be confined to the skin (cutaneous) or it can affect many different organs of the body such as the kidneys, central nervous system, heart, gastrointestinal tract, and lungs.

What is hypersensitivity Angiitis?

Hypersensitivity angiitis is a disease in which patients present with palpable purpura dominant on the lower legs. As lesions evolve they become confluent, and sometimes hemorrhagic and ulcerate. Other organ systems may be involved, particularly the joints, gastrointestinal tract, and kidneys.

What are the different types of vasculitis?

Types of Vasculitis

• Behcet’s Disease.
• Buerger’s Disease (Thromboangiitis Obliterans)
• Eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg Strauss)
• Cryoglobulinemia.
• Giant Cell Arteritis.
• Henoch-Schönlein Purpura.
• Microscopic Polyangiitis.
• Polyarteritis Nodosa.

What is Leukocytoclastic vasculitis?

Leukocytoclastic vasculitis is a small vessel vasculitis characterized histopathologically by immune complex-mediated vasculitis of the dermal capillaries and venules. Cutaneous leukocytoclastic vasculitis is usually confined to skin with rare extracutaneous manifestations in less than 30% of the cases.

How is Leukocytoclastic vasculitis diagnosed?

Skin biopsy with direct immunofluorescence is the cornerstone for the diagnosis of leukocytoclastic vasculitis. Workup for an underlying disease should be undertaken based on clinical suspicion.

What is a Leukocytoclastic vasculitis?

What causes hypersensitivity?

Hypersensitivity syndrome is caused by a complex set of interactions between a medication, your own immune system, and viruses in your body, especially herpes viruses.

How do you differentiate hypersensitivity types?

The four types of hypersensitivity are:

1. Type I: reaction mediated by IgE antibodies.
2. Type II: cytotoxic reaction mediated by IgG or IgM antibodies.
3. Type III: reaction mediated by immune complexes.
4. Type IV: delayed reaction mediated by cellular response.

What causes Leukocytoclastic vasculitis?

Other causes of small vessel vasculitis or leukocytoclastic vasculitis include drug-induced vasculitis, paraneoplastic vasculitis, and infection associated vasculitis (hepatitis B, hepatitis C, syphilis).