What are the symptoms of specific antibody deficiency?

People with selective antibody deficiency do not produce antibodies in response to polysaccharide vaccines. Affected people have many sinus and lung infections and sometimes symptoms of allergies, such as a chronic runny and stuffy nose (rhinitis), a rash, and asthma. The severity of the disorder varies.

What does it mean if your pneumococcal antibodies are low?

When total immunoglobulins or IgG subclasses are low, a more profound immunodeficiency is usually present. Some patients have low antibody titers to Streptococcus pneumoniae during the initial evaluation, and this finding usually requires vaccination and additional testing.

What is specific immune deficiency?

Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination.

Why do I have low antibodies?

Low levels of immunoglobulins mean your immune system isn’t working as well as it should. This can be caused by: Medicines that weaken your immune system, such as steroids. Diabetes complications.

Is specific antibody deficiency a disability?

The Social Security Administration lists immune deficiency disorders under qualifying impairments in the SSA’s Blue Book. If you are disabled because of an immune deficiency disorder, you may qualify for Social Security benefits (SSDI).

Can a person with CVID live normally?

Outlook / Prognosis CVID has no cure. With ongoing treatment, many people with the disorder live active and fulfilling lives. In some cases, complications of CVID such as lung damage or cancer may affect life expectancy.

What is the life expectancy of a person with CVID?

The life expectancy of CVID patients has considerably improved over the past 30 years [5, 63], from initially 12 years to currently over 50 years [3]. Reduced survival was significantly associated with age at diagnosis, lower baseline IgG, higher IgM and fewer peripheral B cells.

How do you treat low antibodies?

Immunoglobulin replacement therapy is a treatment given to boost the IgG antibody levels when they are low. This treatment can strengthen the immune system and help immune deficient patients fight off infections. When someone donates blood, the red cells and plasma are separated.

Can CVID patients get better?

Common variable immunodeficiency (CVID) is an immune system disorder that occurs when a person does not have enough antibodies and becomes susceptible to frequent and potentially severe infections. At this time, CVID cannot be cured.