Does phenytoin increase risk of osteoporosis?
Does phenytoin increase risk of osteoporosis?
There is increasing evidence that anticonvulsant use is associated with a higher risk of osteoporosis and clinical fractures, especially among older agents such as phenobarbital, carbamazepine, phenytoin, and valproate.
What medications make osteoporosis worse?
High doses of corticosteroids.
How does phenytoin affect vitamin D?
Calcium and vitamin D metabolism were evaluated in 5 adult epileptic patients before and during treatment with phenytoin. Significant decreases occurred in serum concentrations of calcium, albumin, and 25-hydroxy-cholecalciferol. The decreases in serum calcium paralleled those in serum albumin.
What medication is the most common cause of drug related osteoporosis?
Epidemiologic studies provide valuable information about medications that place patients at risk for drug-induced osteoporosis. While glucocorticoids (GCs) are most commonly associated with drug-induced osteoporosis, the use of several other therapeutic agents increase the risk of significant bone loss and fracture.
What seizure medications cause osteoporosis?
Some medications used to treat epilepsy can increase your risk of osteoporosis and broken bones….Most of the research in this area has been in people taking the older anti-epileptic drugs such as:
- phenytoin (Epanutin)
- phenobarbital.
- carbamazepine (Tegretol)
- primidone (Mysoline)
- sodium valproate (Epilim)
What medications interfere with calcium absorption?
Common culprits include medications used to treat heartburn and “gastroesophageal reflux disorder” (GERD), such as omeprazole (Prilosec), lansoprazole (Prevacid), and esomeprazole (Nexium). These medications decrease the production of stomach acid, which leads to decreased calcium absorption.
Which drugs inhibit the breakdown of bone?
Medications to Prevent Fragility Fractures
- Alendronate Sodium or Alendronate Sodium plus Vitamin D3 (Fosamax®, Fosamax Plus D and Binosto®)
- Ibandronate Sodium (Boniva®)
- Risedronate Sodium (Actonel®and Atelvia™)
- Zoledronic Acid (Reclast®)
- Denosumab (Prolia®)
- Calcitonin-Salmon (Fortical®and Miacalcin®)
Does phenytoin cause vitamin D deficiency?
As it relates to patients taking phenytoin, it is known that these patients have lower levels of 25-hydroxyvitamin D levels and can begin to manifest as early as 60 days after starting phenytoin.
Can you take calcium with phenytoin?
Interactions between your drugs Using calcium carbonate together with phenytoin may decrease the effects of phenytoin. Separate the times of administration of calcium carbonate and phenytoin by at least two to three hours.
What medications decrease calcium absorption?
Does vitamin D interact with phenytoin?
Long term use of phenytoin (Dilantin) can deplete your vitamin D levels leading to the potential for other problems. Vitamin D is one that we store, so you will have a reserve to last you at first. Eating foods that contain or are fortified with vitamin D, as well as getting plenty of sunshine is a good start.
Does epilepsy medication cause osteoporosis?
Some people who take epilepsy medicines are at risk of decreased bone mineral density. This condition is called osteoporosis. It is a condition that can weaken bones, making them fragile and more likely to break.
How does phenytoin cause osteomalacia?
Osteomalacia with hypocalcemia and elevated alkaline phosphatase levels occurs frequently in patients on long term phenytoin therapy. This has been attributed to both altered metabolism of vitamin D and the inhibition of intestinal absorption of calcium.
What medications block vitamin D absorption?
Drugs That Affect the Absorption of Vitamin D
- Aluminum or Magnesium containing antacids.
- Thiazide and similar diuretics.
- Anticonvulsants (Carbamazepine®)
- St. John’s wort.
- Antiretrovirals (AIDS therapies)
- Alcohol.
- Antirejection medications (after organ transplant)
- Mineral Oil (may influence hypocalcemia)
What drugs cause calcium deficiency?
Which drugs may cause hypocalcemia?
- Radiocontrast.
- Estrogen.
- Loop diuretics.
- Bisphosphonates.
- Calcium supplements.
- Antibiotics.
- Antiepileptic drugs.
- Cinacalcet.
What medications affect calcium absorption?
What drugs cause low calcium?
Drugs like rifampin (an antibiotic), and phenytoin and phenobarbital (anti-seizure drugs) can cause this. Additionally, medicines that fight bone cancers and other bone issues are also linked with hypocalcemia. These drugs include alendronate, ibandronate, risedronate, and zoledronic acid.
Can I take vitamin D with phenytoin?
The biggest thing to know, related to vitamin supplementation while taking this medications involves your vitamin D levels. Long term use of phenytoin (Dilantin) can deplete your vitamin D levels leading to the potential for other problems.
What drugs can affect calcium levels?
Increased calcium in your blood can occur in one of three ways: Increased absorption from your intestines. Decreased excretion through your kidneys….The medicines that have been associated with increased blood calcium levels (hypercalcemia) are:
- Lithium.
- Thiazide diuretics.
- Teriparatide.
- Estrogens.
- Tamoxifen.