What is a Synovasure test?

The Synovasure Lateral Flow Test Kit detects proteins called human alpha defensins in the synovial fluid of patients with a total joint replacement in approximately 10 minutes. Alpha defensins are antimicrobial proteins released by activated neutrophils (white blood cells) in response to infection.

How is a prosthetic joint infection treated?

Prosthetic joint infection usually requires combined medical and surgical therapy. While revision surgery is widely considered to be the gold standard surgical procedure, debridement, antibiotics and irrigation with implant retention is a very appealing alternative.

What is periprosthetic joint infection?

Prosthetic joint infection (PJI), also referred to as periprosthetic infection, is defined as infection involving the joint prosthesis and adjacent tissue.

Can Covid cause joint replacement infection?

Joint replacement infections may occur in the wound or deep around the artificial implants. A new coronavirus disease, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19), hit in December 2019 [1].

What does Synovasure mean?

The Synovasure Alpha Defensin Lateral Flow Test is a standalone, rapid device for detecting alpha defensin in synovial fluid. The test received FDA authorization in 2019 as a CLIA moderately complex test.

What happens if a joint replacement gets infected?

In general, the longer the infection has been present, the harder it is to cure without removing the implant. Late infections (those that occur months to years after the joint replacement surgery) and those infections that have been present for longer periods of time almost always require a staged surgery.

What causes periprosthetic infection?

Acute Periprosthetic Joint Infection Acute infections are usually caused by virulent pathogens, mainlyS. aureus, β-hemolytic streptococci, and less frequently gram-negative bacilli. Most early (postoperative) acute infections have an exogenous origin. Wound dehiscence, drainage, and erythema are typical signs.

Does Covid make arthritis worse?

There are sporadic reports suggesting that some people with COVID-19 developed inflammatory arthritis as a complication of the infection. While COVID-19 survivors have reported muscle and joint pain, there have not been any studies showing that these individuals demonstrated markers of inflammatory arthritis.

Is a bone infection serious?

An infection in your bone can impede blood circulation within the bone, leading to bone death. Areas where bone has died need to be surgically removed for antibiotics to be effective.

Will an xray show bone infection?

A blood test or imaging test such as an x-ray can tell if you have a bone infection. Treatment includes antibiotics and often surgery.

How do you tell if a joint is infected?

Symptoms may include fever, chills, redness at the site of infection, pain or tenderness over the affected bone, and difficulty using the affected limb. They may, for instance, have trouble walking due to severe pain in the legs.

Can knee replacements get infected years later?

Joint replacement infections may occur in the wound or deep around the artificial implants. An infection may develop during your hospital stay or after you go home. Joint replacement infections can even occur years after your surgery.