What are the anti-leprosy drugs?

The three major antileprosy drugs currently in use are 4, 4′-diaminodiphenyl sulfone (DDS, dapsone), rifampicin, and clofazimine.

Which drug is used for both TB and leprosy?

ORGANIZATION OF CLASS

First-Line Drugs	Second-Line Drugs
ISONIAZID	amikacin
PYRAZINAMIDE	aminosalicylic acid
RIFAMPIN	capreomycin
ETHAMBUTOL	cycloserine

What is ROM therapy in leprosy?

leprae can provide an effective single-dose therapy for PB leprosy when combined with rifampicin as ROM (R: Rimfanpicin, O: Ofloxacin, M: Minocycline) regimen. For MB leprosy, 24 monthly doses (pulsed) of supervised ROM can be advocated for patients refusing or unable to take MDT.

How long is Pb treatment?

Patients with fewer bacilli, the paucibacillary (PB) group were recommended to be treated with 2 drugs given for only 6 months, while for the remaining , called the multibacillary (MB) group, 3 drug combination for 2 years or till smear negativity, which ever was later, was advocated.

What are types of leprosy?

Leprosy

• Borderline Lepromatous Leprosy.
• Borderline Tuberculoid Leprosy.
• Indeterminate Leprosy.
• Lepromatous Leprosy.
• Midborderline Leprosy.
• Tuberculoid Leprosy.

What kind of drug is dapsone?

Dapsone , a sulfone, belongs to the family of medicines called anti-infectives. Dapsone is used to treat leprosy (Hansen’s disease) and to help control dermatitis herpetiformis, a skin problem. When it is used to treat leprosy, dapsone may be given with one or more other medicines.

Is isoniazid used in leprosy?

It was concluded that isoniazid is an effective alternate to the sulphone drugs in the treatment of lepromatous leprosy. It is proposed to test further if isoniazid in combination with sulphone drugs will show synergic effects in leprosy similar to those of the combinations used in the treatment of tuberculosis.

How does rifampicin treat leprosy?

Administration of this antibiotic substantially reduces the quantities of M. leprae discharged in the nasal secretions of lepromatous patients within three weeks, thus rapidly decreasing the potential infectivity of these individuals.

Which antibiotic is best for leprosy?

Hansen’s disease is treated with a combination of antibiotics. Typically, 2 or 3 antibiotics are used at the same time. These are dapsone with rifampicin, and clofazimine is added for some types of the disease. This is called multidrug therapy.

What is MB and PB leprosy?

Paucibacillary (PB): includes all smear-negative cases. Multibacillary (MB): includes all smear-positive cases. Classification (clinical): Paucibacillary single lesion leprosy: 1 skin lesion. Paucibacillary leprosy: 2 to 5 patches or lesions on the skin.

Why rifampicin is given monthly in leprosy?

Therefore newer drugs were considered and rifampicin was a logical choice because of its strong bactericidal effect against Mycobacterium leprae, the micro-organism causing leprosy.

What is the brand name of dapsone?

Dapsone

Clinical data
Trade names	Aczone, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682128
License data	US DailyMed: Dapsone

What is dapsone chemical formula?

C12H12N2O2SDapsone / Formula

Is dapsone used in TB?

Dapsone exhibits activity against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC) in vitro. We retrospectively examined the incidence of mycobacterial diseases within a randomized prospective trial of prophylaxis for Pneumocystis carinii pneumonia and toxoplasmosis.

What is clofazimine used for?

Clofazimine is used together with other medicines to treat a form of leprosy (also known as Hansen’s disease), called lepromatous leprosy, including dapsone-resistant lepromatous leprosy, and lepromatous leprosy complicated by erythema nodosum leprosum.

Is there a vaccine for leprosy?

There is no vaccine generally available to specifically prevent leprosy. However, the vaccine against tuberculosis (TB), called the BCG vaccine, may provide some protection against leprosy. This is because the organism that causes leprosy is closely related to the one that causes TB.