Is synaptophysin positive cancer?

Thus, synaptophysin is a specific and fairly sensitive marker for neuroendocrine tumors of both low and high grades of malignancy. The NF proteins are good markers for pheochromocytoma, and their presence is of basic tumor biologic interest and of potential diagnostic value in other neuroendocrine neoplasms.

Is melanoma a neuroendocrine tumor?

Unlike small cell carcinoma which does not express markers of melanocytic differentiation, malignant melanoma can rarely exhibit neuroendocrine differentiation. This case demonstrates the plasticity of malignant melanoma in that it shows extensive neuroendocrine differentiation with CD56, synaptophysin, and INSM1.

What is synaptophysin a marker of?

Synaptophysin, a presynaptic vesicular protein that is often used as a marker for synaptic plasticity and integrity, decreases with increasing age in hippocampal and cortical regions.

What is synaptophysin a marker for?

What is the difference between melanoma and malignant melanoma?

Melanoma is a cancer that begins in the melanocytes. Other names for this cancer include malignant melanoma and cutaneous melanoma. Most melanoma cells still make melanin, so melanoma tumors are usually brown or black. But some melanomas do not make melanin and can appear pink, tan, or even white.

What is the histological appearance of melanoma?

Histological features that favor a diagnosis of melanoma include asymmetry, ulceration, cytological atypia, pagetoid involvement of the epidermis, lack of maturation, and dermal mitosis with deep and atypical ones.

Where does malignant melanoma start?

Melanomas can develop anywhere on the skin, but they are more likely to start on the trunk (chest and back) in men and on the legs in women. The neck and face are other common sites.

Is neuroendocrine tumor grade 1 malignant?

The World Health Organization (WHO) classifies neuroendocrine tumors according to the malignant potential of the tumor: Well-differentiated neuroendocrine tumors (grade 1 and 2) Poorly-differentiated neuroendocrine tumors (grade 3)